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The secondary endpoints include: survival with no or mild neuropsychological impairment at 90 days and at 6, 12 and 24 months, as measured by the MDRS, the Mini-Mental Status Examination (MMSE), and the Glasgow Coma Scale; effect of study medication on quality of life measurements; effect of antiviral therapy on HSV DNA in CSF (measured quantitatively by PCR at Day 0 and Day 90); and safety and tolerance of VACV administered at a dose of 20 grams given orally three times a day for 90 days! It turned into a brown solution after the addition of Et 3N. Consult! Valtrex (Valacyclovir hcl), the valine ester of acyclovir, is an antiviral agent active against herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent cytomegalovirus! Les bénéfices d'un tel traitement prolongé doivent donc être mis en balance avec les risques potentiels! 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